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1

Identification of the hydrophobic strand in the A–B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists

Niv-Spector, Leonora, Gonen-Berger, Dana, Gourdou, Isabelle, Biener, Eva, Gussakovsky, Eugene E., Benomar, Yackir, Ramanujan, Krishnan V., Taouis, Mohammed, Herman, Brian, Callebaut, Isabelle, Djiane,

Journal:

Biochemical Journal

Year:

2005

Language:

english

File:

PDF, 889 KB

english, 2005

2

The obese phenotype-inducing N82K mutation in human leptin disrupts receptor-binding and biological activity

Leonora Niv-Spector, Michal Shpilman, Asaf Grupi, Arieh Gertler

Journal:

Molecular Genetics and Metabolism

Year:

2010

Language:

english

File:

PDF, 292 KB

english, 2010

3

Principles of strategic drug delivery to the brain (SDDB): Development of anorectic and orexigenic analogs of leptin

W.A. Banks, A. Gertler, G. Solomon, L. Niv-Spector, M. Shpilman, X. Yi, E. Batrakova, S. Vinogradov, A.V. Kabanov

Journal:

Physiology & Behavior

Year:

2011

Language:

english

File:

PDF, 364 KB

english, 2011

4

Mapping leptin-interacting sites in recombinant leptin-binding domain (LBD) subcloned from chicken leptin receptor

Niv-Spector, L., Raver, N., Friedman-Einat, M., Grosclaude, J., Gussakovsky, E. E., Livnah, O., Gertler, A.

Journal:

Biochemical Journal

Year:

2005

Language:

english

File:

PDF, 532 KB

english, 2005

5

Pituitary and placental ovine growth hormone variants differ in their receptor-binding ability and in their biological properties

S. Reicher, L. Niv-Spector, A. Gertler, E. Gootwine

Journal:

General and Comparative Endocrinology

Year:

2008

Language:

english

File:

PDF, 632 KB

english, 2008

6

Prolactin affects leptin action in the bovine mammary gland via the mammary fat pad

Feuermann, Y, Mabjeesh, S J, Niv-Spector, L, Levin, D, Shamay, A

Journal:

Journal of Endocrinology

Year:

2006

Language:

english

File:

PDF, 236 KB

english, 2006

7

Preparation and characterization of mouse IL-22 and its four single-amino-acid muteins that act as IL-22 receptor-1 antagonists

Niv-Spector, L., Shpilman, M., Levi-Bober, M., Katz, M., Varol, C., Elinav, E., Gertler, A.

Journal:

Protein Engineering Design and Selection

Year:

2012

Language:

english

File:

PDF, 301 KB

english, 2012

8

Large-scale preparation and characterization of non-pegylated and pegylated superactive ovine leptin antagonist

Leonora Niv-Spector, Michal Shpilman, Yves Boisclair, Arieh Gertler

Journal:

Protein Expression and Purification

Year:

2012

Language:

english

File:

PDF, 1.17 MB

english, 2012

9

Large-scale preparation of biologically active mouse and rat leptins and their L39A/D40A/F41A muteins which act as potent antagonists

Gili Salomon, Leonora Niv-Spector, Eugene E. Gussakovsky, Arieh Gertler

Journal:

Protein Expression and Purification

Year:

2006

Language:

english

File:

PDF, 397 KB

english, 2006

10

Is leptin an important physiological regulator of CRP?

Gertler, Arieh, Niv-Spector, Leonora, Reicher, Shay

Journal:

Nature Medicine

Year:

2007

Language:

english

File:

PDF, 144 KB

english, 2007

11

Pegylated Leptin Antagonist Is a Potent Orexigenic Agent: Preparation and Mechanism of Activity

Elinav, Eran, Niv-Spector, Leonora, Katz, Meirav, Price, Tulin O., Ali, Mohammed, Yacobovitz, Michal, Solomon, Gili, Reicher, Shay, Lynch, Jessica L., Halpern, Zamir, Banks, William A., Gertler, Arieh

Journal:

Year:

2009

Language:

english

File:

PDF, 464 KB

english, 2009

12

Development and Characterization of High Affinity Leptins and Leptin Antagonists

Shpilman, M., Niv-Spector, L., Katz, M., Varol, C., Solomon, G., Ayalon-Soffer, M., Boder, E., Halpern, Z., Elinav, E., Gertler, A.

Journal:

Journal of Biological Chemistry

Year:

2011

Language:

english

File:

PDF, 2.24 MB

english, 2011

13

Leptin signaling and apoptotic effects in human prostate cancer cell lines

Sigal Samuel-Mendelsohn, Michal Inbar, Esther Weiss-Messer, Leonora Niv-Spector, Arieh Gertler, Ronnie J. Barkey

Journal:

Year:

2011

Language:

english

File:

PDF, 2.60 MB

english, 2011

14

Preparation of Leptin Antagonists by Site-Directed Mutagenesis of Human, Ovine, Rat, and Mouse Leptin's Site III : Implications on Blocking Undesired Leptin Action In Vivo

GILI SOLOMON, LEONORA NIV-SPECTOR, DANA GONEN-BERGER, ISABELLE CALLEBAUT, JEAN DJIANE, ARIEH GERTLER

Journal:

Annals of the New York Academy of Sciences

Year:

2006

Language:

english

File:

PDF, 74 KB

english, 2006

15

Pegylated Leptin Antagonist Is a Potent Orexigenic Agent: Preparation and Mechanism of Activity

Elinav, Eran, Niv-Spector, Leonora, Katz, Meirav, Price, Tulin O., Ali, Mohammed, Yacobovitz, Michal, Solomon, Gili, Reicher, Shay, Lynch, Jessica L., Halpern, Zamir, Banks, William A., Gertler, Arieh

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2009

Language:

english

File:

PDF, 22 KB

english, 2009

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